After observing that PI3KО± deletion impaired recovery from tamoxifen Cre toxicity, our primary aim in this study was not to determine the precise mechanism of the resulting cardiomyopathy, but rather to avoid this compounding variable in our study of PI3KО± signalling in relation to heart function, which is why we tested a reduced tamoxifen dose as well as other complementary models of PI3KО± deletion inhibition that do not require tamoxifen finasteride tablets 5mg where to buy PMC free article PMC7299686 PubMed 32565553 CrossRef

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